Design of Sensum+:
Sensum+ patent-pending formula is the result of years of research into the optimal combination of natural oils to condition the specialized skin of the glans and shaft of the penis to provide just the right amount of biofeedback for a majority of men to increase sensitivity.
Ingredients of Sensum+:
Sensum+ is a blend of essential oils and natural botanicals including rose oil, sweet almond oil, cinnamon bark oil, and other extracts. All ingredients in Sensum+ are listed as FDA-GRAS (generally recognized as safe). Sensum+ is manufactured in the United States in an FDA-registered GMP (Good Manufacturing Practices) facility to ensure quality and consistency.
Mechanism of Action of Sensum+:
The main ingredient of Sensum+ (cinnamon oil) works by activating the Transient Receptor Potential A1 (TRPA-1) channels. TRPA1 channels are activated by cinnamon oil (Bandell et al., 2004; Jordt et al., 2004; Bautista et al., 2006) and recent findings have indicated that TRPA1 is involved in mechano-sensation among other actions (Namer et al., 2005; Obata et al., 2005). The mechanism of action is simplified in the figure below. The main ingredient of Sensum+ works by activating the TRPA-1 channels responsible for the heat and cold sensation of the skin and results in an increase of sensation that current users welcome and appreciate.
Cinnamaldehyde is the most specific TRPA1 activator and excites a subset of sensory neurons highly enriched in cold-sensitive neurons to elicits nociceptive behavior Sensum+ increases sensitivity to the skin through exciting the TRPA1 and does not affect the thickness of the skin or the blood flow to the skin.
The mechanism of action of Sensum+ on its ability to increase sensation was determined in a series of animal experiments that measured in a quantitative manner:
- Blood flow to tails of mice treated with Sensum+ daily for fourteen days: As shown in the figure below, treating the tails of mice for fourteen days does not increase the blood flow as compared to the placebo as measure by a laser Doppler.
- Thickness of the epidermis of mice tails treated with Sensum+ daily for fourteen days. As shown in the figure below, treating the tails of mice for fourteen days does not have an effect on the epidermis thickness.
- Increase in Sensitivity. The increase in sensitivity was assessed by measuring the time that mice can keep their tails on a hot plate (Tail Flick model). Mice tails were treated with Sensum+ or placebo daily for seven days. As shown in the figure below, treating the tails of mice with Sensum+ for seven days makes the tail of mice much more sensitive and results in the mice pulling their tails much faster from the hot plate as compared to the placebo treated animals as shown in the figure below.